With years of experience in synthetic and conjugation chemistry, Creative Biolabs is dedicated to helping global clients design and develop highly-customized linker and drug-linker complexes for ADC development through the featured "DrugLnk" services. At Creative Biolabs, many unique compounds have been designed to fulfill clients' special requirements, ranging from traditional payload-linkers containing auristatin or maytansinoid derivatives to more novel warheads such as topoisomerase inhibitors. Presented here is a case study for the synthesis of two customized payload-linker complexes via the "DrugLnk" organic synthesis services.

The following list includes the main content:

1. Introduction
2. SN38: a novel payload for ADC development
3. Case 1: Mc-vc-PAB-SN38
4. Case 2: CL2A-SN38
5. Conclusions